BAN ORL 24 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BAN ORL 24 是一种 NOP 受体拮抗剂。BAN ORL 24 对 NOP 受体有拮抗作用，在 CHO 细胞中，其KI 值为 0.24 nM。BAN ORL 24 可用于癌症和镇痛的研究。

BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic.

BAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC50 values of 50 μM and 0.224 μM, respectively.

BAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception.Animal Model:C57BL/6 mice Dosage:10 mg/kg Administration:10 mg/kg; i.v.Result:Caused inhibition of BPRIM97-induced antinociception at 90-min post injection.Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min.

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Endocrinology/Hormones

Opioid Receptor

Opioid Receptor

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1401463-54-4

506.51

C27H37Cl2N3O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 200 mg/mL (394.86 mM; 超声助溶 ) H2O 中的溶解度 : 100 mg/mL (197.43 mM; 超声助溶)

O=C([C@@H]1N(CCC1)CC2=CC=CC=C2)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years